10 Best Calming Products For Cats 2025 in the United States

The Vetoquinol Zylkene Calming Supplement is designed to help small dogs and cats manage stress from situations like travel, vet visits, or loud noises. Its main calming ingredient, alpha-casozepine, comes from a milk protein, making it a natural option that avoids drowsiness or harsh side effects commonly seen in other calming products.

This supplement is lactose-free and gentle on sensitive stomachs, which is beneficial for cats with digestive sensitivities. The package contains capsules that you open and sprinkle over your pet’s food, making it straightforward to use daily. This daily routine can support behavioral issues and help your cat stay calm during stressful events.

With a solid positive rating from many users, Zylkene offers a safe, gentle, and easy-to-administer way to support your cat’s relaxation. Pet owners should monitor their cat’s response and ensure proper dosing.

The FELIWAY Optimum Enhanced Calming Pheromone is a 30-day refill designed to reduce stress-related behaviors in cats, such as scratching, urine spraying, and excessive hiding. As a non-sedating and drug-free solution, it releases pheromone analogs to provide a natural, reassuring message to cats, helping them feel more at ease. This product is easy to use—simply plug the diffuser into an open outlet with good air circulation, and it will work continuously for up to 30 days.

It’s important to use the FELIWAY diffuser with its specific refills for optimal results. One diffuser covers up to 700 square feet, and it should be replaced every six months, with refills changed monthly. Backed by over 25 years of research and recommended by vets, it’s a reliable choice for many cat owners.

However, it may not be universally effective for all cats, and the need to replace refills and diffusers regularly could be a recurring cost. Additionally, while it is safe for cats, humans, and other pets, it carries a specific scent (Mimosa) that may not appeal to everyone. This product is most beneficial for cat owners dealing with noticeable signs of feline stress in their homes.

The FELIWAY Optimum diffuser uses synthetic pheromones designed to mimic natural calming signals cats give each other, making it a drug-free and non-sedating option. This makes it a good fit for cat owners looking for a safe, gentle way to reduce stress-related behaviors like spraying, scratching, and fearfulness. It works continuously for up to 30 days per vial, covering about 700 square feet, which suits most home environments with one or two diffusers. It’s simple to use—just plug into an outlet with some open space around it for best effect—and designed specifically for cats, so it won’t affect people or other pets. Users report significant reductions in common stress behaviors, which supports its effectiveness.

Because it relies on pheromones, results can vary from cat to cat depending on individual preferences and sensitivity. The diffuser must be replaced every six months and only with official FELIWAY refills, which adds some ongoing cost and limits flexibility with third-party products. Placement matters, too; it shouldn’t be hidden behind furniture or near litter boxes to work well.

While some cats respond quickly, others might take longer or need additional calming support. FELIWAY Optimum is a trusted, veterinarian-recommended calming product best suited for cat owners who want a safe, easy-to-use, and steady way to ease their cat’s stress without medication, though it requires monthly maintenance and careful placement for best results.